Sökning: "Metabolic Profiling"

Visar resultat 41 - 45 av 66 avhandlingar innehållade orden Metabolic Profiling.

1. 41. Between two lungs : proteomic and metabolomic approaches in inflammatory lung diseases

   Författare :Tina Heyder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This doctoral thesis presents results on proteomic and metabolomic profiling of two distinct inflammatory lung diseases: sarcoidosis and chronic obstructive pulmonary disease (COPD). Chronic inflammatory lung diseases are debilitating conditions representing a major health problem throughout the world. LÄS MER

3. 42. Integration of functional genomics and data mining methodologies in the study of bipolar disorder and schizophrenia

   Författare :Marianthi Logotheti; Nikolaos Venizelos; Fragiskos Kolisis; Nikos Stefanis; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar Disorder; Schizophrenia; Fibroblasts; DNA Microarrays; Machine Learning; Functional Analysis; Gene Expression; Transcriptomics;

   Sammanfattning : Bipolar disorder and schizophrenia are two severe psychiatric disorders characterized by a complex genetic basis, coupled to the influence of environmental factors. In this thesis, functional genomic analysis tools were used for the study of the underlying pathophysiology of these disorders, focusing on gene expression and function on a global scale with the application of high-throughput methods. LÄS MER

4. 43. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure

   Författare :Andrea Treyer; Per Artursson; Gert Fricker; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular drug bioavailability; unbound drug concentration; drug disposition; ADME; drug transport; drug metabolism membrane partitioning; phospholipid; drug-drug interaction; antisense oligonucleotide; cell-penetrating peptide; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. LÄS MER

5. 44. Alternative pathways in the plant respiratory chain -transgenic analyses of type II NAD(P)H dehydrogenases

   Författare :Sabá Wallström; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : During oxidative phosphorylation, the production of ATP is driven by the activity of several proton-pumping respiratory protein complexes. In plants, non-proton pumping type II NAD(P)H dehydrogenases are also present in the respiratory chain to oxidize cytosolic and matrix NAD(P)H. LÄS MER

7. 45. Towards transcriptome-wide studies of mRNA translation in tissues from cancer patients

   Författare :Shuo Liang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Gene expression consists of multiple strictly regulated steps, including transcription, RNA modification, splicing, messenger RNA (mRNA) transport, mRNA degradation, mRNA translation and protein degradation. mRNA translation, the most energy consuming step, plays a critical role in gene expression via global and selective control of protein synthesis. LÄS MER