Sökning: "Lung fibroblasts"

Visar resultat 21 - 25 av 41 avhandlingar innehållade orden Lung fibroblasts.

  1. 21. Inflammatory mechansims in pulmonary sarcoidosis

    Författare :Mary Berlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adhesion molecules; alveolitis; bronchoalveolar lavage; bronchial hyperreactivity; extracellular matrix molecules; extrinsic allergic alveolitis; fibrosis; HLA-DR; sarcoidosis; TCR;

    Sammanfattning : Pulmonary sarcoidosis is an inflammatory disorder of unknown aetiology, characterised by an accumulation of CD4+ T-cells in the alveolar compartment and by granuloma formation and varying degrees of interstitial fibrosis. The initial clinical presentation may either be acute with fever, malaise, arthritis and/or erythema nodosum or insidious with cough, dyspnea, tiredness, and loss of weight. LÄS MER

  3. 22. Of voles and men : novel Hantavirus in vitro models

    Författare :Karin Sundström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hantavirus-infection can cause severe disease in humans, with up to 40% case fatalities. Presently, no therapeutics or prophylaxis against hantaviral illness exists. The mechanisms underlying the onset of symptoms and the following pathogenesis are not fully known. LÄS MER

  4. 23. Studies on neurotrophins in inflammatory pulmonary diseases

    Författare :Charlotta Dagnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Asthma, sarcoidosis and chronic obstructive pulmonary disease (COPD) are inflammatory pulmonary diseases, all being characterized by tissue inflammation, tissue damage (airway remodeling) and loss of lung function. In order to increase possibilities to find new biomarkers, drug targets and better treatment options for the patients, further research on the underlying mechanisms driving the inflammation and airway remodeling in these diseases are required. LÄS MER

  5. 24. Chemoattractant receptors in drug discovery : FPR2 and CCR2-two potential targets

    Författare :Christina Kalderén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemoattractants and chemoattractant receptors have many important functions in multicellular organisms, not least for their role in regulating migration of leukocytes. The receptors are also involved in many pathologies and they have, since they were cloned in the 1990ies, been regarded as attractive targets for development of drugs against cancer, viral infections, and inflammatory/autoimmune diseases. LÄS MER

  7. 25. Intrapulmonary insulin : Experimental and clinical studies

    Författare :Johan H. Jendle; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : After intrapulmonary insulin administration was first reported in 1925, the development of highly efficient nebulisers has once again made this area interesting. Therefore, the distribution and retention of aerosol produced by a new jet nebuliser was evaluated in an animal model. LÄS MER