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1. 1. Protein folding without loops and charges

   Författare :Martin Kurnik; Mikael Oliveberg; Kevin W. Plaxco; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; folding cooperativity; protein aggregation; protein charges; protein engineering; Biochemistry; biokemi;

   Sammanfattning : Going down the folding funnel, proteins may sample a wide variety of conformations, some being outright detrimental to the organism. Yet, the vast majority of polypeptide molecules avoid such pitfalls. Not only do they reach the native minimum of the energy landscape; they do so via blazingly fast, biased, routes. LÄS MER