Sökning: "Immunologi transplantation serologi transplantation serology Immunology allograft xenograft heart transplantation tolerance anti-LFA-1 CTLA4Ig anti-CD40L"

Hittade 1 avhandling innehållade orden Immunologi transplantation serologi transplantation serology Immunology allograft xenograft heart transplantation tolerance anti-LFA-1 CTLA4Ig anti-CD40L.

1. 1. Induction of operational tolerance to allografts and xenografts

   Författare :Matthias Corbascio; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; allograft; xenograft; heart transplantation; tolerance; anti-LFA-1; CTLA4Ig; anti-CD40L;

   Sammanfattning : Inhibition of the costimulatory molecules B7 and CD40L with CTLA4Ig and anti-CD40L administered only during the first week after transplantation induces indefinite survival of allo- and xenogeneic heart transplants and significantly prolongs skin grafts in C3H mice. However, this treatment protocol is not as effective in C57BL/6 mice which reject skin transplants with nearly the same median survival time as untreated controls. LÄS MER