Sökning: "Idiopathic inflammatory myopathies"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden Idiopathic inflammatory myopathies.

1. 11. Risk factors and outcomes in inflammatory myopathies

   Författare :Valérie Leclair; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Idiopathic inflammatory myopathies (IIM) are complex autoimmune diseases associated with high morbidity and mortality. Although knowledge about the pathogenic mechanisms underlying IIM is improving, limited data are available to inform clinical decision-making contributing to overall poor clinical outcomes in that population. LÄS MER

3. 12. Autoantibodies and the type I interferon system in idiopathic inflammatory myopathies

   Författare :Louise Ekholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Idiopathic inflammatory myopathies (IIM), also known as myositis, are rare autoimmune diseases, characterized by proximal muscle weakness and inflammatory cells in skeletal muscle tissue. The most common subgroups are polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). LÄS MER

4. 13. Studies on pathogenesis, clinical features and comorbidities of idiopathic inflammatory myopathies

   Författare :Antonella Notarnicola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Idiopathic inflammatory myopathies (IIM), a group of rare chronic inflammatory disorders, are characterized by a broad spectrum of clinical manifestations with high morbidity and mortality. The pathogenesis of IIM is largely unknown but accumulating evidence suggests that autoantibodies promote the initiation and perpetuation of the disease. LÄS MER

5. 14. Studies of immunopathogenic mechanisms and treatment of chronic, inflammatory myopathies, myositis

   Författare :Maryam Dastmalchi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Idiopathic inflammatory myopathies; polymyositis; dermatomyositis; IVIg; infliximab treatment; physical training; muscle biopsy;

   Sammanfattning : Polymyosit (PM), dermatomyositis (DM) and sporadic inclusion body myositis (sIBM) are chronic inflammatory myopathies which are characterized by muscle weakness, fatigue and extra-muscular involvement. Mononuclear inflammatory cells are typically found in muscle tissue. LÄS MER

7. 15. T cell subsets and disease mechanisms in inflammatory myopathies

   Författare :Jayesh Pandya; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic muscle disorders, typically displaying infiltrating T cells in skeletal muscle tissue and classified into polymyositis, dermatomyositis and sporadic inclusion body myositis. Several studies involving both humans and animal models point towards a role for T cells in the pathogenesis of IIMs, however, the precise phenotype, functionality and specificity of pathogenic T cells remain elusive. LÄS MER