Sökning: "GSNO"

Hittade 5 avhandlingar innehållade ordet GSNO.

  1. 1. Effects of nitric oxide on hemostasis with special attention to platelet function

    Författare :Johanna Albert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :nitric oxide; bleeding time; platelet aggregation; platelet secretion; P-selectin expression; flow cytometry; NG-monomethyl-L-arginine; L-NMMA; nasal air; skin perfusion; GSNO; humans;

    Sammanfattning : Endogenous endothelium-derived NO provides a continuous vasodilating effect, but may also in humans have an antithrombotic effect, which is exerted by inhibition of platelet function and by vasodilatation. Inhalation of NO selectively relaxes the pulmonary vascular bed, without causing systemic hypotension. LÄS MER

  3. 2. Gene expression in buccal keratinocytes with emphasis on carbonyl metabolism

    Författare :Claudia A Staab; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The inner lining of the cheek, the buccal mucosa, is a target for air-borne, dietary and tobacco usage-derived carcinogens, but also interesting from a drug delivery point of view. Cancer arising in the buccal epithelium, buccal squamous cell carcinoma (BSCC), often diagnosed at a late disease stage, is highly aggressive and recurrent, emphasizing the need for novel approaches in diagnosis and therapy. LÄS MER

  4. 3. Functional Aspects of Epithelia in Cystic Fibrosis and Asthma

    Författare :Zhanna Servetnyk; Godfried Roomans; Michael Wilschansky; Uppsala universitet; []
    Nyckelord :Cell biology; cystic fibrosis; CFTR; chloride transport; airway epithelium; sweat gland; asthma; corticosteroids; montelukast; Cellbiologi;

    Sammanfattning : The cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel in the apical membrane of epithelial cells, is defective in patients with cystic fibrosis (CF). Research efforts are focused on chloride channel function in order to find a cure for the disease. LÄS MER

  5. 4. Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase

    Författare :Jesper Hedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alcohol dehydrogenase 3 (ADH3), identical to glutathione-dependent formaldehyde dehydrogenase, plays a vital role in the defense against formaldehyde through the activity for the spontaneously formed adduct between formaldehyde and glutathione, Shydroxymethylglutathione (HMGSH). ADH3 may also participate in the metabolism of Snitrosylated glutathione, GSNO. LÄS MER

  7. 5. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation

    Författare :Seyed Isaac Hashemy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. LÄS MER