Sökning: "platelet secretion"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden platelet secretion.

  1. 1. Platelet Adhesion to Proteins in Microplates : Applications in Experimental and Clinical Research

    Författare :Andreas Eriksson; Per Whiss; Håkan Wallén; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; platelet adhesion; platelet assay; synergistic activation; thrombosis; anti-platelet treatment; Pharmacology; Farmakologi;

    Sammanfattning : Platelets are crucial for prevention of blood loss after vessel injury. Platelet adhesion to disrupted vessel walls is mediated by receptors such as the GPIb-IX-V complex that binds von Willebrand factor and the collagen-binding integrin α2β1. LÄS MER

  3. 2. Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis

    Författare :Rundk Hwaiz; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; abdominal sepsis; Rac1; platelet; neutrophil; chemokine; inflammation;

    Sammanfattning : Sepsis is a systemic inflammatory response syndrome to a localized or systemic infection that leads to the over production of proinflammatory cytokines and the ultimate failure of multiple organ systems. However, little is known about the potential role of Rac1 in controlling sepsis-induced intracellular signaling pathways. LÄS MER

  4. 3. The Role of Chlamydia pneumoniae-induced Platelet Activation in Cardiovascular Disease : In vitro and In vivo studies

    Författare :Hanna Kälvegren; Torbjörn Bengtsson; Arina Richter; Erik Kihlström; Kenneth Persson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia pneumoniae; Platelet; atherosclerosis; Infection; LDL-oxidation; Percutaneous coronary intervention; Cardiovascular disease; Serotonin; Reactive oxygen species production; Pharmacology; Farmakologi;

    Sammanfattning : The common risk factors for atherosclerosis, such as obesity, high cholesterol levels, sedentary lifestyle, diabetes and high alcohol intake, only explain approximately 50% of cardiovascular disease events. It is thereby important to identify new mechanisms that can stimulate the process of atherosclerosis. LÄS MER

  5. 4. Formation and Relevance of Platelet Subpopulations

    Författare :Anna Södergren; Sofia Ramström; Karin Öllinger; Riitta Lassila; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Platelets are important players in the hemostatic system, acting as guardians of vessel integrity. When they come across a breach in the vessel wall, they quickly adhere to the damaged surface, secrete activating and adhesive compounds from their secretory granules, recruit additional platelets into a growing platelet plug and support the action of the coagulation system. LÄS MER

  7. 5. The role of platelet thrombin receptors PAR1 and PAR4 in platelet activation

    Författare :Karin Vretenbrant Öberg; Tomas Lindahl; Sofia Ramström; Johan Heemskerk; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Platelets play a pivotal role in coagulation and haemostasis. Their most prominent task is to seal damaged blood vessels by the formation of a platelet plug at the damaged area. Once the injury is covered, platelets retract the coagulum to close the wound and allow the blood to flow freely in the vessel. LÄS MER