Sökning: "FoxP3"

Visar resultat 16 - 20 av 96 avhandlingar innehållade ordet FoxP3.

  1. 16. CD25+CD4+ regulatory T cells in rheumatic disease

    Författare :Duojia Cao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human; rheumatic disease; synovial fluid; regulatory T cells; FOXP3; suppression; tolerance; autoimmunity;

    Sammanfattning : CD25+CD4+ T cells represent a unique cell lineage of thymus derived naturally occurring regulatory T cells. The gene Foxp3 (mouse)/ FOXP3(human) is strictly related to their generation in the thymus and their regulatory function in the periphery. LÄS MER

  3. 17. On the immunopathogenesis of HIV infection

    Författare :Jakob Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human Immunodeficiency Virus-1; Lymphoid tissue; cell mediated immunity; CD8 T-cells; perforin; cytotoxicity; regulatory T-cells; FOXP3;

    Sammanfattning : CD8+ T-cell dependent clearance of microbial infections by perforin mediated killing of infected cells is a central component in the combat against viral infections. In HIV-1 infected individuals the incidence of virus infected cells in lymphoid tissue, which is the major site for virus production, does not drop, but instead slowly increases as the disease progresses. LÄS MER

  4. 18. Cell transplantation with human mesenchymal or embryonic stem cells to the heart : experimental, molecular, immunological and echocardiographic studies

    Författare :Karl-Henrik Grinnemo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human mesenchymal stem cells; human embryonic stem cells; human cardiomyocyte; Islet-1; Nkx2.5; stem cell; xenotransplantation; rejection; FoxP3 T-cells; tolerance; CTLA4Ig; anti- CD40L; LFA-1;

    Sammanfattning : Background: Human mesenchymal stem cells (hMSC), human embryonic stem cells (HESC) and human fetal cardiomyocyte progenitor cells (HFCP) all represent possible candidate cells for regeneration of damaged myocardium. Although they represent cell types with many positive attributes, their capacity to engraft, to differentiate into mature cardiomyocytes, to improve myocardial function and their immunological properties are the focus of these studies. LÄS MER

  5. 19. Regulatory T cells : molecular and clinical aspects

    Författare :Malin E Winerdal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the immune system’s tug of war with cancer, tolerance mechanisms by which the tumor can control anti-tumor immune responses play a central role in determining the outcome. Regulatory T cells (Treg) induced in the thymus or the periphery, represent one such tolerance mechanism that potentially can be exploited by developing tumors. LÄS MER

  7. 20. Regulatory T cells in rheumatoid arthritis : contributions from different functional subsets

    Författare :Jessica Alexandra Herrath; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a complex and multifactorial disease characterized by chronic joint inflammation and tissue destruction, which can affect all ethnic groups with a prevalence of 0.5-1%. LÄS MER