Sökning: "Human Immunodeficiency Virus-1"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Human Immunodeficiency Virus-1.
1. Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
Sammanfattning : The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. LÄS MER
2. On the immunopathogenesis of HIV infection
Sammanfattning : CD8+ T-cell dependent clearance of microbial infections by perforin mediated killing of infected cells is a central component in the combat against viral infections. In HIV-1 infected individuals the incidence of virus infected cells in lymphoid tissue, which is the major site for virus production, does not drop, but instead slowly increases as the disease progresses. LÄS MER
3. Chemokines and chemokine receptors during viral infections in man
Sammanfattning : Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal centers in lymphoid tissue. LÄS MER
4. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies
Sammanfattning : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. LÄS MER
5. The EBV-HIV interrelationship and the value of EBV-DNA analysis
Sammanfattning : Epstein-Barr virus (EBV) infects the vast majority of humans and resides latently in B-cells. This virus carries genes that can induce and sustain mature B cell growth. EBV is associated with a wide range of B-cell lymphomas including Burkitt lymphoma and non Hodgkin lymphoma (NHL) in human immunodeficiency virus 1 (HIV-1) infected patients. LÄS MER