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Visar resultat 1 - 5 av 21 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Study of phages for phage therapy : An Escherichia coli experience

    Författare :Mohammadali Khan Mirzaei; Anders Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The world is rapidly moving toward a post-antibiotic era as effective antibiotics are becoming fewer. phage therapy is a potentially possible method for treating infectious diseases and counts as an alternative method for antibiotic therapy. LÄS MER

  3. 2. Site-specific recombination in P2-like coliphages

    Författare :Carlos Cardoso Palacios; Elisabeth Haggård-Ljungquist; Didier Mazel; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The scope of these studies has been to investigate the site-specific recombination systems of P2-like coliphages, both in an evolutionary perspective by a comparative analysis of related phages as well as in a functional perspective. Surveys of P2-like phages in Escherichia coli isolated from nature reveal the existence of seven discrete immunity classes and three integration sites, one of them previously unknown. LÄS MER

  4. 3. Bacterial viruses targeting multi-resistant Klebsiella pneumoniae and Escherichia coli

    Författare :Harald Eriksson; Anders Nilsson; Elisabeth Haggård-Ljungquist; Klas Flärdh; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bacterial viruses; Bacteriophage; Phage; Phage therapy; multi-resistant bacteria; Klebsiella pneumoniae; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The global increase in antibiotic resistance levels in bacteria is a growing concern to our society and highlights the need for alternative strategies to combat bacterial infections. Bacterial viruses (phages) are the natural predators of bacteria and are as diverse as their hosts, but our understanding of them is limited. LÄS MER

  5. 4. Site-Specific Recombination : Integrases, Accessory Factors and DNA Targets of P2-like Coliphages

    Författare :Lina Sylwan; Elisabeth Haggård-Ljungquist; Margaret C. M. Smith; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The temperate coliphage P2 and its family members integrate their genomes into the host Escherichia coli chromosome by a site-specific recombination mechanism to form lysogeny. Integration takes place between the complex phage attP site and the simple bacterial attB site and is catalyzed by the phage encoded integrase (Int). LÄS MER

  7. 5. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

    Författare :Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. LÄS MER