Sökning: "Phage therapy"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden Phage therapy.

  1. 1. Bacterial viruses targeting multi-resistant Klebsiella pneumoniae and Escherichia coli

    Författare :Harald Eriksson; Anders Nilsson; Elisabeth Haggård-Ljungquist; Klas Flärdh; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bacterial viruses; Bacteriophage; Phage; Phage therapy; multi-resistant bacteria; Klebsiella pneumoniae; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The global increase in antibiotic resistance levels in bacteria is a growing concern to our society and highlights the need for alternative strategies to combat bacterial infections. Bacterial viruses (phages) are the natural predators of bacteria and are as diverse as their hosts, but our understanding of them is limited. LÄS MER

  3. 2. Study of phages for phage therapy : An Escherichia coli experience

    Författare :Mohammadali Khan Mirzaei; Anders Nilsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The world is rapidly moving toward a post-antibiotic era as effective antibiotics are becoming fewer. phage therapy is a potentially possible method for treating infectious diseases and counts as an alternative method for antibiotic therapy. LÄS MER

  4. 3. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy

    Författare :Andreas Wisniewski; Sophia Hober; Masood Kamali-Moghaddam; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Autoimmune diseases; Cancer; Half-life extension; HRP; Phage Display; Protein Engineering; Targeted therapy; Biotechnology; Bioteknologi;

    Sammanfattning : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. LÄS MER

  5. 4. Site-specific recombination of P2-like phages; possible tools for safe gene therapy : A focus on phage ΦD145

    Författare :Sridhar Mandali; Elisabeth Haggård-Ljungquist; Richard Calendar; Stockholms universitet; []
    Nyckelord :bacteriophage; integrase; site-specific recombination; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Sammanfattning : P2-like bacteriophages integrate their genome into the E. coli host cell by a site-specific recombination event upon lysogenization. The integrative recombination occurs between a specific sequence in the phage genome, attP, and a specific sequence in the host genome, attB, generating the host-phage junctions attL and attR. LÄS MER

  7. 5. Infection kinetics, phylogenetics, and host interactions of bacteriophages

    Författare :Shazeeda Koonjan; Anders S. Nilsson; Lone Brøndsted; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacteriophage biology; infection kinetics; phylogenetics; host interactions; phage therapy; phage ecology and evolution; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Bacteriophages, or as they are most commonly referred to as phages, are viruses which are capable of infecting bacteria. They are environmentally plenty, found everywhere from the ground we walk on to contributing to our microbiome. They are highly diverse, coming in various sizes, shapes, and genomic compositions. LÄS MER