Sökning: "Cervical neoplasia"

Visar resultat 16 - 20 av 40 avhandlingar innehållade orden Cervical neoplasia.

  1. 16. Human papillomavirus infection, genetic instability and invasive properties of cervical lesions

    Författare :Barbro Skyldberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical neoplasia; HPV; ISH; PCR; centrosomes; genetic stability; laminin-5;

    Sammanfattning : Cancer of the uterine cervix is one of the most frequent malignancies in women worldwide. Approximately half a million new cases of cervical cancer are diagnosed each year, and about 200 000 women die from the disease. Human papillomavirus (HPV) DNA has been shown to be present in about 90 % of all cervical cancers. LÄS MER

  3. 17. Human papilloma virus : association with vulvovaginitis and genital intra-epithelial neoplasia

    Författare :Elisabeth Bodén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In many women with gynecological complaints such as itching, burning, discharge, and fissures causing dyspareunia, examination of the vulvovaginal mucosa reveals hyperkeratotic and papillomatous changes. Polymerase Chain Reaction (PCR) technique revealed 64% of such lesions to harbour Human Papilloma Virus (HPV)- DNA, whereas Southern blot (SB) technique showed 50% to be positive for HPV- DNA. LÄS MER

  4. 18. HLA predisposition to human papillomavirus induced cervical neoplasia : population based studies from the Västerbotten county in northern Sweden

    Författare :Mehran Ghaderi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infection with human papillomaviruses (HPV) types 16 and 18 is the major cause of cervical neoplasia. Although a high proportion of cervical cancers (CXCA) harbor HPV genomes, only a small number of women infected with high-risk papillomaviruses develop cervical tumors, suggesting that other environmental and/or genetic factors contribute to cervical carcinogenesis. LÄS MER

  5. 19. Optimizing cervical cancer prevention through screening and HPV vaccination

    Författare :Klara Miriam Elfström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Effective primary and secondary prevention tools exist for cervical cancer in the form of human papillomavirus (HPV) vaccines and cervical screening. In order to maximize the impact of prevention strategies in Sweden and European countries, this thesis sought to investigate the long-term effectiveness of different screening strategies and the long-term risk associated with HPV infections, the organization and quality of existing screening programs, and the effectiveness of alternative vaccination strategies. LÄS MER

  7. 20. Human papillomavirus testing and its application in cervical cancer prevention

    Författare :Anna Söderlund Strand; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping method that uses mass spectrometry for detection of the products of type-specific mass extend reactions, and a method with particularly sensitive detection of a broad spectrum of HPV-types, also in the case of multiple infections, that uses type-specific probes coupled to fluorescent beads for detection on the Luminex platform. LÄS MER