Sökning: "laminin-5"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet laminin-5.

  1. 1. Human papillomavirus infection, genetic instability and invasive properties of cervical lesions

    Författare :Barbro Skyldberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical neoplasia; HPV; ISH; PCR; centrosomes; genetic stability; laminin-5;

    Sammanfattning : Cancer of the uterine cervix is one of the most frequent malignancies in women worldwide. Approximately half a million new cases of cervical cancer are diagnosed each year, and about 200 000 women die from the disease. Human papillomavirus (HPV) DNA has been shown to be present in about 90 % of all cervical cancers. LÄS MER

  3. 2. Endometrial carcinoma : prognostic factors and protein expression profiling

    Författare :Caroline Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endometrial carcinoma; prognosis; DNA ploidy; MIB-1; p53; laminin-5 72 chain; 2DE;

    Sammanfattning : Endometrial carcinoma is the most common gynaecological cancer in the western world. It is usually diagnosed at an early stage since it presents with irregular vaginal bleeding when the tumour is still limited to the uterus and the prognosis is generally favourable. LÄS MER

  4. 3. Molecular markers reflecting malignant transformation and tumor progression

    Författare :Patricia Stoltzfus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Molecular markers; interphase fluorescence in situ hytidization; genetic diagnostic test; laminin-5 gamma2 chain; immunohistochemistry; precancerous lesions; invasiveness; breast cancer; cervical squamous cell carcinoma; tongue carcinoma; vulvar carcinoma;

    Sammanfattning : The early detection of neoplastic lesions is most critical in the successful treatment of malignant disease. This thesis investigates molecular targets for an improved detection and diagnosis of cancer by exploring the value of interphase fluorescence in situ hybridization (FISH) to detect specific chromosomal aneuploidies and gene amplifications, and laminin-5 gamma2 chain expression detected by immunohistochemistry as a marker for invasiveness. LÄS MER

  5. 4. Methods for early diagnosis of head and neck cancer

    Författare :Sushma Nordemar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Head and neck; laminin5; cystic metastasis; ICM DNA-analysis; aneuploidy;

    Sammanfattning : Head and Neck squamous cell cancer (HNSCC) is the fifth most common malignancy in the western countries and in Sweden it comprises 2- 3% of all cancer cases. Alcohol and tobacco are known as principal etiological factors but other carcinogenic attributes i.e. viruses and bethel chewing have also been recognised. LÄS MER

  7. 5. Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy

    Författare :Alexander Nyström; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vasculature; angiogenesis; Medicine human and vertebrates ; disease; LG domains; Laminin; Medicin människa och djur ;

    Sammanfattning : Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. LÄS MER