Sökning: "CXCL12"

Visar resultat 16 - 20 av 30 avhandlingar innehållade ordet CXCL12.

  1. 16. Mesenchymal niche contribution to normal and malignant hematopoiesis

    Författare :Lakshmi Sandhow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Normal hematopoiesis is tightly regulated by hematopoietic microenvironment/niche in bone marrow (BM) via direct hematopoietic cell-niche cell interaction and factors secreted by various types of cellular niches. The BM niche consists of cells of mesenchymal cell origin including mesenchymal stem cells (MSCs) and progenitor cells (MPCs). LÄS MER

  3. 17. T Cell Ontogeny and Effector Functions in Galphai2-deficient Colitis

    Författare :Malin Bjursten; Göteborgs universitet; []
    Nyckelord :colitis; T cells; Galphai2- - mice; thymus; pro-inflammatory cytokines; alpha4 integrin;

    Sammanfattning : Inflammatory bowel disease (IBD) comprising Crohn s disease and ulcerative colitis is a disease that affects millions of people worldwide, especially in northern countries such as Sweden, and is characterised by chronic uncontrolled inflammation of the intestinal mucosa. It is the general belief that multiple factors such as genetic and environmental aspects are involved in disease pathogenesis. LÄS MER

  4. 18. Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors

    Författare :Daniel Hägerstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are brain tumors that currently are treated with surgery, radiation and chemotherapy. Less than 7.5% of patients with GBM survive more than 2 years after diagnosis. LÄS MER

  5. 19. Compartmentalisation of the immune response in human skin : cross-talk between dendritic cells and T cells in healthy conditions and in psoriasis

    Författare :Elisa Martini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human skin is highly compartmentalised and distinct subsets of dendritic cells (DCs) and T cells reside in epidermis and dermis. Alterations in the composition of DCs and T cells have been observed in psoriasis, a common cytokine-driven focal inflammatory skin disease. LÄS MER

  7. 20. The role of cannabinoid receptors, G alpha z, and B cell receptor in lymphoma pathobiology with focus on chemotaxis

    Författare :Magali Merrien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia (CLL) are two incurable B cell malignancies, with an overall survival of 5 to 8 years and 6 to 10 years, respectively. Therapies are available but are often very aggressive, and patients relapse due to minimal residual disease. LÄS MER