Sökning: "Binuclear"

Visar resultat 1 - 5 av 31 avhandlingar innehållade ordet Binuclear.

  1. 1. Quantum Chemical Modeling of Binuclear Zinc Enzymes

    Författare :Shilu Chen; Fahmi Himo; Luca De Gioia; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantum Chemical Modeling; Binuclear; Zinc; Enzyme; DFT; Mechanism; Theoretical chemistry; Teoretisk kemi;

    Sammanfattning : In the present thesis, the reaction mechanisms of several di-zinc hydrolases have been explored using quantum chemical modeling of the enzyme active sites. The studied enzymes are phosphotriesterase (PTE), aminopeptidase from Aeromonas proteolytica (AAP), glyoxalase II (GlxII), and alkaline phosphatase (AP). LÄS MER

  3. 2. On semirigid binuclear ruthenium complexes and DNA : binding modes and kinetics

    Författare :Fredrik Westerlund; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; binding kinetics; polarized light spectroscopy; threading; intercalation; SDS-sequestered dissociation; FRET; DNA; ruthenium complexes;

    Sammanfattning : .... LÄS MER

  4. 3. Structural Requirements for Selective DNA Binding - Studies on Mono- and Binuclear Ruthenium Complexes

    Författare :Johanna Andersson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ruthenium; enantioselectivity; sequence selectivity; spectroscopy; threading intercalation; calorimetry; kinetics; DNA; cell studies;

    Sammanfattning : Ever since the discovery of the role of DNA as the template for protein synthesis, efforts have been made to develop DNA targeted drugs. One of the major challenges in the design of DNA binding drugs is to achieve selective binding to specific DNA sequences, which is crucial to avoid side effects. LÄS MER

  5. 4. On Thallium (III) and binuclear platinum-thallium complexes with N-donor ligands in solution and in solid

    Författare :Guibin Ma; KTH; []
    Nyckelord :thallium; platinum; cyanide; n-donor ligand; metal-metal bond multinuclear NMR; raman spectroscopy;

    Sammanfattning : This thesis describes the synthesis, structure, equilibriaand other properties of novel thallium(III) monomeric andplatinum-bonded complexes with nitrogen donor ligandsethylenediamine, diethylenetriamine, triethylenetetramine,porphyrin, 2,2'-bipyridine and 1,10-phenanthroline in solutionand in solid.The existence of three complexes withthe general formula[Tl(en)n]3+(n = 1-3) and their overall stability constantshave been established in pyridine. LÄS MER

  7. 5. Control Mechanisms of Electron and Proton Transfer in Cytochrome c Oxidase

    Författare :Martin Karpefors; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Cytochrome c oxidase is a remarkable molecular machine that is bound in the inner mitochondrial membrane or in the cell membrane of bacteria. Using the free energy that is released when electrons from foodstuff are transferred to molecular oxygen, protons are translocated from the inner to the outer side of the membrane. LÄS MER