Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Gene-environment interactions for arsenic metabolism and metal-related oxidatively generated DNA damage

    Författare :Karin Engström; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AS3MT; methylation; polymorphism; 8-oxodG;

    Sammanfattning : Over 100 million people around the world are exposed to high concentrations of arsenic (As) in drinking water, associated with a number of adverse health effects such as skin, lung and bladder cancer, vascular diseases and diabetes. In humans, As is metabolized via alternating reduction and methylation reactions, from inorganic As (iAs) into monomethylated (MMA) and dimethylated As (DMA). LÄS MER

  3. 2. Factors influencing the metabolism of inorganic arsenic in humans

    Författare :Anna-Lena Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arsenic; AS3MT; Gender differences; GSTO1; Metabolism; Methylation; MTHFR; Nutrition; Polymorphisms;

    Sammanfattning : Inorganic arsenic (iAs), a naturally occurring drinking water contaminant, is a potent human carcinogen and toxicant. It is believed that in humans, as well as in most mammals, inorganic arsenic is biotransformed via reduction and methylation using one-carbon metabolism with S-adenosyl methionine (SAM) as methyl donor, and is excreted mainly in urine as dimethylarsinate (DMA) and methylarsonate (MA) as well as some unmethylated iAs (arsenate (As(V)) and arsenite (As(III)). LÄS MER

  4. 3. Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes

    Författare :Jessica De Loma Olson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. LÄS MER