Sökning: "upper motor neuron"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden upper motor neuron.

1. 1. On the Site of the Lesion in Konzo : Clinical and Neurophysiological Studies on a Non-Progressive Upper Motor Neuron Disorder

   Författare :Desire Tshala-Katumbay; Andrew Eisen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Konzo; upper motor neuron diseases; WHO criteria; electroencephalography; evoked potentials; brain involvement; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : Konzo is a permanent spastic para/tetraparesis occurring in undernourished populations in Africa relying on insufficiently processed bitter cassava, which contains cyanogenic compounds, as staple food. Its pathogenetic mechanism is unknown. Our studies aimed at clarifying the lesion in konzo. LÄS MER

3. 2. Upper and Lower Motoneuron Lesions in Tetraplegia - Diagnostic and Therapeutic Implications of Electrical Stimulation

   Författare :Ines Bersch; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electrical stimulation; Tetraplegia; Upper motoneuron lesion; Lower motoneuron lesion; Motor point topography; Nerve transfer;

   Sammanfattning : The overall objective of this thesis was to improve outcomes and predictability of the treatment of upper extremity function in patients with cervical spinal cord injury and tetraplegia by advancing the diagnostic and therapeutic tools employed in upper and lower motor neuron lesions. An overview is presented of the current knowledge about the principles of electrical stimulation and its usefulness and proven effects on the upper limb. LÄS MER

4. 3. Amyotrophic lateral sclerosis (ALS) associated with superoxide dismutase 1 (SOD1) mutations in British Columbia, Canada : clinical, neurophysiological and neuropathological features

   Författare :Heather G. Stewart; Hiroshi Mitsumoto; Umeå universitet; []
   Nyckelord :ALS; SOD1; complete penetrance; incomplete penetrance; mis-diagnosis; upper motor neuron; clinical neurophysiology; transcranial magnetic stimulation; peristimulus time histogram; corticospinal pathway; cortical inhibition; cortical hyper-excitability;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by loss of motor neurons and their supporting cells in the brain, brainstem and spinal cord, resulting in muscle paresis and paralysis including the bulbar (speech, chewing, swallowing) and respiratory muscles. The average age at onset is 55 years, and death due to respiratory failure occurs 2-5 years after symptom onset in ~ 85% of cases. LÄS MER

5. 4. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

   Författare :Hanna Wootz; Dan Lindholm; Håkan Aldskogius; Christopher Fowler; Uppsala universitet; []
   Nyckelord :Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

   Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. LÄS MER

7. 5. Spasticity after first-ever stroke

   Författare :Erik Lundström; Jörgen Borg; Andreas Terént; Anja Smits; Christian Blomstrand; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; spasticity; upper motor neuron syndrome; UMN syndrome; prevalence; incidence; prediction; disabling spasticity; Neurology; Neurologi; Rehabilitation Medicine; Rehabiliteringsmedicin; Neurology; Neurologi;

   Sammanfattning : The prevalence of spasticity after first-ever stroke is approximately 20%, but there are no data on the prevalence of disabling spasticity.The reported prevalence of pain after stroke varies between 19% and 74%, whether pain is associated with spasticity is not known. LÄS MER