Sökning: "triggered release"
Visar resultat 11 - 15 av 115 avhandlingar innehållade orden triggered release.
11. Modulation of cytochrome c release by mitochondrial redox status and caspase-2
Sammanfattning : The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of the hemoprotein from its binding to the inner mitochondrial membrane, followed by its release into the cytosol through pores in the outer mitochondrial membrane - an event that is usually triggered by proapoptotic Bcl-2 family proteins, such as Bid, Bax and Bak. LÄS MER
12. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems
Sammanfattning : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. LÄS MER
13. Mitochondrial involvement in cell death : release of pro-apoptotic proteins
Sammanfattning : In addition to the role of the mitochondria in energy metabolism, these organelles play a key role in cell death signaling. In particular, mitochondrial alterations, such as stimulation of reactive oxygen species (ROS) formation, decreased ATP synthesis, loss of membrane potential and the release of pro-apoptotic proteins from the mitochondrial intermembrane space (IMS), have been shown to be involved in, and often responsible for, various manifestations of cell death. LÄS MER
14. Bioaccessibility, corrosion and surface properties of metals, alloys and metallic powder in biological fluids of relevance for occupational and consumer health hazard assessment
Sammanfattning : When assessing hazards of metals, alloys, and metal-containing items, the metal release (bioaccessibility) is of high importance. Triggered by increasingly stricter hazard classifications for metals, especially cobalt (Co), and limited knowledge, the aim of this doctoral thesis is to assess correlations between the metal/alloy surface characteristics, corrosion and metal release pattern in different simulated biological fluids relevant to human exposure scenarios (dermal, ingestion and inhalation, Papers I-V). LÄS MER
15. All-Photonic Control of Biorelevant Processes using Molecular Photoswitches and Caged Compounds
Sammanfattning : The development of light-controlled molecular tools for in situ regulation of biological activity holds great promise e.g. for resolving dynamic aspects of cellular signal transduction and to overcome inherent pharmaceutic limitations such as poor drug selectivity. LÄS MER
