Sökning: "cytochrome c release"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden cytochrome c release.

  1. 1. Proton, Electron, and O2 transfer in Cytochrome c Oxidase

    Författare :Lina Salomonsson; Peter Brzezinski; Marilyn Gunner; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton pumping; kinetic isotope effect; Biochemistry; Biokemi;

    Sammanfattning : In mitochondria and aerobic bacteria energy conservation involves electron transfer through the membrane-bound protein of the respiratory chain to oxygen. Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water. Part of the energy released in this reaction is used to pump protons across the membrane. LÄS MER

  3. 2. Modulation of cytochrome c release by mitochondrial redox status and caspase-2

    Författare :Mari Enoksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Apoptosis; cytochrome c release; mitochondria; Glutaredoxin; glutathione;

    Sammanfattning : The release of cytochrome c is an important event during apoptosis, induced by diverse stimuli. Our laboratory has previously proposed that cytochrome c release occurs via a two-step process, involving the detachment of the hemoprotein from its binding to the inner mitochondrial membrane, followed by its release into the cytosol through pores in the outer mitochondrial membrane - an event that is usually triggered by proapoptotic Bcl-2 family proteins, such as Bid, Bax and Bak. LÄS MER

  4. 3. Active Transport of Ions across Biomembranes : A Kinetic Study of Cytochrome c Oxidase Reconstituted into Phospholipid Vesicles

    Författare :Kristina Faxén; Peter Brzezinski; Pia Ädelroth; Thomas E. DeCoursey; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton pumping; kinetic isotop effect; ion pumping; flow flash; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Ion transport across membranes is of uttermost importance for us. It is the foundation for signaling of various kinds e.g. in the nerve-system. LÄS MER

  5. 4. Prokaryotic respiratory supercomplexes : Studies of interactions between complexes III and IV

    Författare :Olga Stah; Pia Ädelroth; Petra Hellwig; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bioenergetics; membrane protein; bacterial respiration; electron transport chain; supercomplex; cytochrome c oxidase; membrane-anchored cytochrome c; cytochrome bc1 complex; electron transfer; proton transfer; time-resolved spectroscopy; apoptosis; biokemi; Biochemistry;

    Sammanfattning : Respiratory processes for cellular energy conversion are carried out by the membrane-associated enzymes of the electron transfer chain (ETC). In recent years there has been emerging data showing that the members of the ETC organize into higher-level assemblies called supercomplexes (SCs) whose functional relevance is not yet fully understood. LÄS MER

  7. 5. Structural studies of ba3-type cytochrome c oxidase using serial crystallography and X-ray absorption spectroscopy

    Författare :Doris Zoric; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ba3-type cytochrome c oxidase; structural biology; X-rays; serial X-ray crystallography; X-ray absorption spectroscopy; enzyme reaction dynamics;

    Sammanfattning : Cytochrome c oxidase (CcO) catalyses the reduction of molecular oxygen to water while the energy released in this process is used transport protons “up-hill” across an energy transducing biological membrane, creating a proton-motive force for ATP synthesis. Given its key role in energy transduction in organisms, proton pumping has been extensively studied across species. LÄS MER