Sökning: "transient gene expression"

Visar resultat 1 - 5 av 150 avhandlingar innehållade orden transient gene expression.

  1. 1. Gene and protein expression in denervated atrophic and hypertrophic skeletal muscle

    Författare :Marlene Norrby; Sven Tågerud; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Skeletal muscle; Denervation; Hypertrophy; Atrophy; Gene expression; Protein expression; Protein phosphorylation; NIFK; Wnt; MK2; Akt signaling;

    Sammanfattning : Following denervation skeletal muscles change their functional and structural properties. Some changes resemble conditions in developing muscles and may be important for reinnervation. Due to inactivity following denervation most skeletal muscles loose muscle mass and become atrophic. LÄS MER

  3. 2. Global Profiling of Host Cell Gene Expression During Adenovirus Infection

    Författare :Fredrik Granberg; Hongxing Zhao; Ulf Pettersson; Richard Roberts; Uppsala universitet; []
    Nyckelord :Genetic engineering; Adenovirus; Microarray; Gene expression; Host-virus interaction; Genteknik;

    Sammanfattning : To investigate mechanisms involved in virus-host interactions, global changes in host gene expression were examined during infection with adenovirus type 2 (Ad2) using cDNA microarray technology. In paper I and II, transcriptional changes in HeLa cells were investigated during the early and late phase of infection, respectively. LÄS MER

  4. 3. GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

    Författare :Anna Barlind; Göteborgs universitet; []
    Nyckelord :Growth hormone; rat; hypophysectomy; vascular resistance; gene expression; place learning; Intellicage; hexarelin; CNS; hippocampus; neurogenesis; cell survival; mouse;

    Sammanfattning : Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments presenting in the survivors. For both these conditions, it is important to develop new therapeutic strategies. LÄS MER

  5. 4. Changes in gene expression during delayed neuronal death after cerebral ischemia in the rat

    Författare :Fredrik Kamme; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; ischemia; brain; neuronal death; gene expression; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : After transient global cerebral ischemia, selected populations of neurons in the brain will die after a period of 2-3 days, a phenomenon termed delayed neuronal death. This is of clinical importance as delayed neuronal death has been found to occur in humans as well. LÄS MER

  7. 5. Design, expression, and analysis of antibody-based blood-brain barrier shuttles

    Författare :Andrés de la Rosa; Greta Hultqvist; Paul O'Callaghan; Nicole G. Metzendorf; Torben Moos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody therapeutics; transient gene expression; protein production; blood-brain barri-er BBB ; BBB shuttle; brain delivery; Transferrin receptor TfR ; heparan sulfate; holo-transferrin; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Antibody therapeutics, with their strong and highly selective target binding, are now used to treat various diseases. However, to enable their use to treat brain disorders, they must be delivered across the blood-brain barrier (BBB), as without active transport, only around 0.01% of intravenously injected doses reach the brain. LÄS MER