Sökning: "plasminogen activator inhibitor type-1"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden plasminogen activator inhibitor type-1.
1. Plasminogen activator inhibitor type-1 : structure-function studies and its use as a reference for intramolecular distance measurements
Sammanfattning : Inhibitors belonging to the serpin (serine protease inhibitor) family control proteases involved in various physiological processes. All serpins have a common tertiary structure based on the dominant b-sheet A, but they have different inhibitory specificity. LÄS MER
2. Food intake, fibrinolysis and risk factors for cardiovascular disease : studies with special focus on plasminogen activator inhibitor type 1 (PAI-1)
Sammanfattning : Elevated plasminogen activator inhibitor (PAI-1) activity levels, hyperlipemia, hypertension, impaired glucose tolerance and obesity, in particular central obesity, are all related to increased risk for the development of cardiovascular disease.Some risk factors are known to be and shown to be influenced by dietary habits. LÄS MER
3. Mechanisms and effects of low plasminogen activator inhibitor type 1 activity
Sammanfattning : Bleeding diathesis is a common reason for investigation of the haemostatic system and in about 50% of the cases an abnormality is found. Plasminogen activator inhibitor type 1 (PAI-1) is an inhibitor of tissue- and urokinase plasminogen activator (tPA/uPA). LÄS MER
4. Regional fluxes of tissue plasminogen activator in porcine endotoxemia
Sammanfattning : Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator of intravascular fibrinolysis with plasminogen activator inhibitor type-1, PAI-1, as its main inhibitor. LÄS MER
5. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease
Sammanfattning : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. LÄS MER