Sökning: "C-peptide"
Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet C-peptide.
1. Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide
Sammanfattning : Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. LÄS MER
2. Molecular aspects of proinsulin C-peptide interactions
Sammanfattning : Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (C-peptide), which are released into the circulation. LÄS MER
3. Intracellular and peptide interactions of C-peptide
Sammanfattning : Proinsulin C-peptide is depleted together with insulin in type I diabetic patients. The supplement of insulin to these patients is necessary for their survival, but it is also likely that the loss of C-peptide may contribute to both short- and long-term complications. In this thesis, molecular effects of C-peptide have been investigated. LÄS MER
4. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide
Sammanfattning : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. LÄS MER
5. Proinsulin C-peptide : membrane interactions and intracellular signaling
Sammanfattning : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. LÄS MER
