Sökning: "lung deposition"

Visar resultat 16 - 20 av 47 avhandlingar innehållade orden lung deposition.

  1. 16. Particles in small airways : mechanisms for deposition and clearance and pharmacokinetic assessments of delivered dose to the lung

    Författare :Maria Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung deposition; clearance; small airways; pharmacokinetic; cystic fibrosis; primary ciliary dyskinesia; asthma; sodium cromoglycate;

    Sammanfattning : BACKGROUND: Knowledge about lung deposition and clearance from airways of inhaled particles/drugs are essential for evaluation of health effects of inhaled pollutants and to achieve optimal drug dose to the lung. The primary defence mechanism in the conducting airways is the mucociliary clearance (MCC). LÄS MER

  3. 17. Modeling nanofiber transport and deposition in human airways

    Författare :Sofie Högberg; Geoff Gibson; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Strömningslära; Fluid Mechanics;

    Sammanfattning : An understanding of the complex motion of fibrous particles is important in a wide range of areas, including inhalation toxicology, targeted drug delivery, composites manufacturing, paper making, and food processing. While the applications are diverse, the governing equations for the fiber motion may be shared. LÄS MER

  4. 18. Tomographic ventilation-perfusion lung scintigraphy in cardiopulmonary disease

    Författare :Jonas Jögi; Lund Klinisk fysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Technegas; Ventilation-Perfusion Single Photon Emission Computed Tomography; Chronic obstructive pulmonary disease; Heart failure; Pulmonary embolism;

    Sammanfattning : Respiration relies, among other things, on the balance between regional ventilation and perfusion in the lungs. There are many cardiopulmonary diseases, such as pulmonary embolism (PE), chronic obstructive pulmonary disease (COPD) and left heart failure (LHF), which can affect respiration negatively. LÄS MER

  5. 19. Deposition and clearance of inhaled particles in patients with obstructive airway diseases

    Författare :Katharina Svartengren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bronchial asthma; chronic bronchitis; immotile-cilia syndrome; tracheobronchial clearance; mucus; cough; particle deposition; laryngoscopy; lung function;

    Sammanfattning : A large part of the population (at least 10%) suffers from asthma or chronic bronchitis. Knowledge of deposition and clearance of inhaled particles in the respiratory tract in this group of patients is essential for estimating environmental health hazards, as well as optimal effects of therapeutic aerosols. LÄS MER

  7. 20. Structure of the distal lung studied with inhaled nanoparticles

    Författare :Madeleine Petersson Sjögren; Metalund; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Techniques able to detect impairments in the distal human lung are lacking. Since inhaled nanoparticles are predominantly deposited in the acini, their deposition can be used to derive structural properties of the region. Intheory, structural enlargements in the distal lung imply that less inhaled nanoparticles deposit there. LÄS MER