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Visar resultat 1 - 5 av 47 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Charting the human lung with inhaled nanoparticles : Development of AiDA - a new diagnostic technique for respiratory disease

   Författare :Jonas Jakobsson; NanoLund: Centre for Nanoscience; []
   Nyckelord :Aerosol; lung; lung deposition; respiratory tract; nanoparticles; ultrafine particles; airspace dimension assessment; AiDA; Chronic obstructive pulmonary disease; COPD; lung morphology;

   Sammanfattning : Changes to the smallest structures of the distal lung are often the first sign of severe respiratory disease, but to date methods to detect and quantify these changes are limited. Chronic obstructive pulmonary disease (COPD) is currently estimated to be the third most common cause of death worldwide, but is to a large extent under-diagnosed, especially at early stages. LÄS MER

3. 2. Experimental Determination of the Deposition of Aerosol Particles in the Human Respiratory Tract

   Författare :Jakob Löndahl; Kärnfysik; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nanoparticles; deposition; respiratory tract; health; air pollution; aerosol particle; ultrafine particles; lung; Fysicumarkivet A:000;

   Sammanfattning : BACKGROUND: Aerosol particles have, since the antiquity, been linked to adverse effects on human health. It is estimated that the particles in urban air pollution cause at least 100,000 deaths in Europe each year, whereof 5,000 in Sweden. LÄS MER

4. 3. Deposition and absorption of inhaled drugs

   Författare :Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER

5. 4. Methodological studies on lung deposition : evaluation of inhalation devices and absorption mechanisms

   Författare :Lars Borgström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Sammanfattning : .... LÄS MER

7. 5. Neonatal resuscitation - studies in piglets

   Författare :Rikard Linnér; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Newborn resuscitation; birth asphyxia; cerebral oxygenation; adrenaline; noradrenaline; severe hypoventilation; surfactant; nebulisation; vibrating mesh nebuliser. CPAP; lung deposition; lung distribution.;

   Sammanfattning : Background and aims: “It’s best to start with air” states the current guidelines on the resuscitation of babies at birth. In a piglet model mimicking severe neonatal asphyxia and circulatory arrest, different aspects of resuscitation were investigated (studies I-III). LÄS MER