Sökning: "lung deposition"

Visar resultat 21 - 25 av 47 avhandlingar innehållade orden lung deposition.

  1. 21. Airborne particulate matter in a Sub-Saharan Africa city: Nairobi, Kenya, and at an Equatorial high altitude site: Mount Kenya

    Författare :Samuel Mwaniki Gaita; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; X-ray Fluorescence XRF ; Particle Induced X-ray Emission PIXE ; Particulate matter pollutants; Source apportionment; sub-Saharan Africa; Deposition fractions; High- altitude; Free troposphere; Spatial distribution;

    Sammanfattning : In Sub-Saharan Africa (SSA), air quality is gravely understudied despite the existing influential factors such a rapid urbanization and population growth that negatively affect the environment. Majority of urban areas in SSA face challenges that include lack of social services, poor infrastructure development, exponential increase of second-hand vehicles and extensive use of biomass-based fuel for energy needs. LÄS MER

  3. 22. A novel technology for studying the disposition of drugs and toxicants in the lung : short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols

    Författare :Pär Ewing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aerosol; inhalation; rat; lung; absorption; drugs; carcinogen; particles;

    Sammanfattning : The disposition of solutes following the deposition of inhaled substances in the lung is a complex process that proceeds along parallel paths; passive diffusion of solutes through the air/blood barrier and local metabolism followed by blood-borne clearance to the circulation. Using the isolated and perfused lung (IPL) the pulmonary disposition of inhaled particles can be studied in great detail without interference from distal organs and systemic exposure. LÄS MER

  4. 23. Characterisation of aerosol delivery devices and their influence on deposition in humans and animals

    Författare :Ola Nerbrink; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One way of administrating pharmaceutical drugs in the development phase and in the clinical situation is by inhalation. It is essential to ensure an accurate delivered dose, as the prediction of the effect and side effects of the drug action is dependent on a precise estimation of the given dose. LÄS MER

  5. 24. Radiation induced pneumonitis : clinical and experimental studies with special emphasis on the effect of smoking

    Författare :Kenneth Nilsson; Leif Bjerner; roger Henriksson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pneumonitis; irradiation; bronchoalveolar lavage; breast cancer; interstitial lung disease; hyaluronan; mast cell; smoking;

    Sammanfattning : Bronchoalveolar lavage (BAL) is an established method providing diagnostic support and evaluation of disease activity in interstitial lung disease (ILD). The aims of the present investigation were 1) to study the inflammatory response in pneumonitis evoked by irradiation. LÄS MER

  7. 25. Potential mechanisms for acute health effects and lung retention of inhaled particles of different origin

    Författare :Anna Klepczynska Nyström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Environmental particle exposure is known to have negative health effects. There is limited knowledge about how size and origin of particles influence these effects. There is also little known regarding the fate of ultrafine particles (particles in nanosize;< 100 nanometers in diameter) after being inhaled. LÄS MER