Sökning: "epileptiform activity"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden epileptiform activity.

  1. 1. Speech and language dysfunction in childhood epilepsy and epileptiform EEG activity

    Författare :Gunilla Rejnö-Habte Selassie; Göteborgs universitet; []
    Nyckelord :auditory ability; cognition; co-morbidity; epilepsy; epileptiform activity; follow-up; Landau Kleffner syndrome; language disorder; neurodevelopmental dysfunction; speech disorder;

    Sammanfattning : In severe childhood language disorder, concomitant dysfunction in other areas may be present. There are indications that epileptiform EEG activity and epilepsy may influence speech and language development, but this relationship is poorly understood. LÄS MER

  3. 2. Gene Therapy for Neurological Disorders

    Författare :Jan Tönnesen; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epileptiform activity; striatum; organotypic culture; electrophysiology; Wnt5a; synaptic connectivity.; cell transplantation; hippocampus; neural stem cells; epilepsy; functional integration; Parkinson’s disease; optogenetics; Gene therapy;

    Sammanfattning : Gene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. LÄS MER

  4. 3. Source localisation of epileptiform activity in epilepsy of temporal lobe origin

    Författare :Göran Lantz; Klinisk neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; frequency analysis; ictal; singe photon emission computed tomography; volume conduction; extracranial; intracranial; LORETA; dipole; source localisation; epilepsy; mesolimbic; Fast Fourier Transform; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : In patients with drug resistant partial epilepsy, who are under consideration for epilepsy surgery, interictal and ictal EEG recorded with extracranial electrodes plays an important role in the localisation of the seizure onset area. During the past years, methods have been developed, which can be used to estimate the location of the source of epileptiform activity in the brain from extracranial EEG data. LÄS MER

  5. 4. Pharmacodynamics of low-dose clonazepam in children with epilepsy or spasticity : neurophysiological and clinical studies

    Författare :Maria Dahlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Children; epilepsy; spasticity; AED; clonazepam; seizures; electroencephalography; magnetoencephalography; dynamometer;

    Sammanfattning : In children with epilepsy the evaluation of the efficacy of an antiepileptic drug (AED) is usually made by recording the seizure frequency. Some seizures are subtle and difficult to detect and epileptiform activity even without clinical seizures may cause cognitive dysfunctions. LÄS MER

  7. 5. Role of Neuropeptides and Neurotrophic Factors in Seizure Modulation

    Författare :Avtandil Nanobashvili; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; neurophysiology; brain slice; entorhinal cortex; hippocampus; galanin; glial cell line-derived neurotrophic factor; neuropeptide Y; epilepsy; kindling; Neurology; neurofysiologi; neuropsykologi; Neurologi;

    Sammanfattning : The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2 (GFRa2), as well as neuropeptide Y (NPY) and galanin and their receptors in modulation of seizure activity. We demonstrate that mice lacking the GFRa2 gene (GFRa2-/-) exhibit suppressed seizure generalization in traditional and rapid kindling models. LÄS MER