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Visar resultat 1 - 5 av 28 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Arthritogenecity of RNA and its degradation products

    Författare :Fariba Zare; Göteborgs universitet; []
    Nyckelord :dsRNA; ssRNA; virus; arthritis; TLR3; IL-1R; IFNalpha beta receptor; plasminogen; tissue factor; uric acid; inflammation; arthritis; neutrophils;

    Sammanfattning : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). LÄS MER

  3. 2. Translational studies of viral-induced asthma and COPD exacerbations

    Författare :Irma Mahmutovic Persson; Respiratorisk immunofarmakologi; []
    Nyckelord :Asthma; exacerbation models; COPD; dsRNA; Th2; Virus; house dust mites HDM ; TSLP; IL-1β; IL-25; IL-33;

    Sammanfattning : .... LÄS MER

  4. 3. Targeting viral induced TSLP - an airway treatment opportunity

    Författare :Angelica Brandelius; Respiratorisk immunofarmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Respiratory viral infections cause exacerbations of asthma and COPD that cannot be effectively treated today. Thymic Stromal Lymphopoietin (TSLP) is an upstream epithelial cytokine linking the innate and adaptive immune system. Viral stimuli induce epithelial overexpression of TSLP in asthma and COPD. LÄS MER

  5. 4. Studies of the Effect of Enterovirus Infection on Pancreatic Islet Cells

    Författare :Asma Basheir Elshebani; Gun Frisk; Heiki Hyöty; Uppsala universitet; []
    Nyckelord :Medical sciences; type 1 diabetes; Human pancreatic islets; β-cells; chemokines; enterovirus; MEDICIN OCH VÅRD;

    Sammanfattning : Enterovirus (EV) infections have been associated with the pathogenesis of Type 1 Diabetes (T1D). However, the pathway(s) by which EV may induce or accelerate diabetes is not well understood. LÄS MER

  7. 5. The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells

    Författare :Magdalena Prahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor suppressor p53 is a critical regulator of life and death in cells. The p53 protein is present at very low levels in cells under normal conditions but accumulates in response to different stress stimuli, such as DNA damage, hypoxia, and oncogene activation. LÄS MER