Sökning: "cancer immune"

Visar resultat 1 - 5 av 544 avhandlingar innehållade orden cancer immune.

  1. 1. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER

  3. 2. Mechanisms for immune escape in epithelial ovarian cancer

    Författare :Pernilla Israelsson; Ulrika Ottander; Lucia Mincheva-Nilsson; Eva Lundin; Ivan Nagaev; Karin Sundfeldt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; ovarian cancer; high-grade serous cancer; EOC; HGSC; HGSOC; tumor microenvironment; immune escape; immune suppression; cytokines; exosomes; NKG2D; MICA B; ULBP1-3; DNAM-1; surgery; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. LÄS MER

  4. 3. Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease

    Författare :Moa Lindgren; Hanna Nyström; Ingrid Ljuslinder; Malin Sund; Kristian Pietras; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; breast cancer; breast cancer metastases; tumor marker; biomarker; stroma; type IV collagen;

    Sammanfattning : Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. LÄS MER

  5. 4. Cancer and Inflammation : Role of Macrophages and Monocytes

    Författare :Alexander Hedbrant; Jonny Wijkander; Dick Delbro; Ann Erlandsson; Anita Sjölander; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; M1 macrophages; M2 macrophages; colon cancer; lung cancer; prostaglandin E2; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Macrophages are cells of the innate immune system that can be found in large quantities in cancer tumors and affect cancer progression by regulating growth and invasiveness of cancer cells. There are two main phenotypes of macrophages denoted M1 and M2. LÄS MER

  7. 5. Spatial immune analyses in clinical cancer tissue

    Författare :Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. LÄS MER