Sökning: "exacerbation models"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden exacerbation models.
1. On causes and regulation of anti-viral defence in asthma and COPD
Sammanfattning : Rhinovirus infection is a main trigger of asthma and COPD exacerbations. dsRNA, a viral replication intermediate, is sensed by pattern recognition receptors in the airway epithelium leading to down-stream induction of anti-viral interferons. LÄS MER
2. Translational studies of viral-induced asthma and COPD exacerbations
Sammanfattning : .... LÄS MER
3. Development and Resolution of Allergic Airway Inflammation in vivo: effects of therapeutic intervention
Sammanfattning : Eosinophils, containing tissue toxic granule proteins, are regarded a culprit cell in asthma pathogenesis. Using animal and human experimental models of asthma effects on eosinophilic airway inflammation were investigated in vivo. LÄS MER
4. Targeting the IL-33/ST2 pathway in asthma : implications for development, exacerbation and treatment
Sammanfattning : Asthma is a term that encompasses a disease spectrum with different phenotypes that vary in severity and whose common characteristic is airflow limitation. Allergic asthma is the most common phenotype of asthma and is characterized by allergen induced inflammatory responses, airway hyperresponsiveness (AHR), and remodeling. LÄS MER
5. Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions
Sammanfattning : It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against inhaled particles, pathogens and toxic agents. LÄS MER