Sökning: "dsRNA"
Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet dsRNA.
1. Arthritogenecity of RNA and its degradation products
Sammanfattning : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). LÄS MER
2. Translational studies of viral-induced asthma and COPD exacerbations
Sammanfattning : .... LÄS MER
3. Targeting viral induced TSLP - an airway treatment opportunity
Sammanfattning : Respiratory viral infections cause exacerbations of asthma and COPD that cannot be effectively treated today. Thymic Stromal Lymphopoietin (TSLP) is an upstream epithelial cytokine linking the innate and adaptive immune system. Viral stimuli induce epithelial overexpression of TSLP in asthma and COPD. LÄS MER
4. Studies of the Effect of Enterovirus Infection on Pancreatic Islet Cells
Sammanfattning : Enterovirus (EV) infections have been associated with the pathogenesis of Type 1 Diabetes (T1D). However, the pathway(s) by which EV may induce or accelerate diabetes is not well understood. LÄS MER
5. The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
Sammanfattning : The tumor suppressor p53 is a critical regulator of life and death in cells. The p53 protein is present at very low levels in cells under normal conditions but accumulates in response to different stress stimuli, such as DNA damage, hypoxia, and oncogene activation. LÄS MER