Sökning: "cytochrome P-450"

Visar resultat 16 - 20 av 25 avhandlingar innehållade orden cytochrome P-450.

  1. 16. Characterization of xenobiotic metabolism in the feral teleost northern pike (Esox lucius)

    Författare :Lennart Balk; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : A basic characterization of xenobiotic metabolism in the feral teleost Northern pike has been performed. The different aspects of concern have been:a) investigation of the uptake and distribution to different body compartments of the carcinogen and environmental pollutant benzo(a)pyrene using whole-body autoradiography and scintillation counting. LÄS MER

  3. 17. Microsomal glutathione transferase

    Författare :Ralf Morgenstern; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : A distinct glutathione transferase which can be activated up to eightfold by sulfhydryl reagents was discovered in rat liver microsomes. This enzyme was subsequently purified to apparent homogeneity in 40 % yield using column cromatography. LÄS MER

  4. 18. Cellular toxicity of quinones : Redox- and addition chemistry

    Författare :Karin Öllinger; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Quinoid compounds are widely occurring in nature. They have cytotoxic properties and they are also used as antineoplastic agents. The cytotoxic properties can be explained by the ability of quinones to generate active oxygen species by redox cycling, by addition to cellular nucleophiles, and by inhibition of DNA transcription. LÄS MER

  5. 19. Glyceryl Trinitrate Distribution and the "Remarkable Tolerance"

    Författare :Kristina E. Torfgård; Matts Henning; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : To study the distribution of glyceryl trinitrate (GTN), a gas chromatographic method was developed for simultaneous determination of GTN and its dinitrate metabolites in 'plasma and tissues. The distribution of GTN and 1 ,3-g1yceryl dinitrate (1,3-GDN) and 1,2-glyceryl dinitrate (1,2-GDN) was studied in GTN tolerant and nonto1erant rats. LÄS MER

  7. 20. Cholesterol homeostasis in the brain : importance of 24S-hydroxylation

    Författare :Dieter Lütjohann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. We have investigated whether side chain-hydroxylated cholesterol species are important for elimination of cholesterol from the brain. About 80% of 24S-hydroxycholesterol (24S-OH-Chol) present in the body is present in the brain. LÄS MER