Sökning: "Karin Öllinger"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Karin Öllinger.

  1. 1. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

    Författare :Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. LÄS MER

  3. 2. Head and Neck Cancer : Factors Affecting Tumour Growth

    Författare :Kaarina Sundelin; Elisabeth Paulette-Hultcrantz; Karin Öllinger; Karin Roberg; Hans Gustafsson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; Chemoradiotherapy; Tumour; Malignant salivary; Metallothionein; Neo-angiogenesis; Metastases; Cytokine tumour necrosis factor-alpha; hepatocyte growth factor; Oncology; Onkologi;

    Sammanfattning : Head and neck cancer is the fifth most common cancer worldwide with an estimated annual global incidence of over 500 000 cases. These malignant tumours develop in the mucosal linings of the upper respiratory tract or in the salivary glands. The most common sites are in the oral cavity and larynx. LÄS MER

  4. 3. Cellular toxicity of quinones : Redox- and addition chemistry

    Författare :Karin Öllinger; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Quinoid compounds are widely occurring in nature. They have cytotoxic properties and they are also used as antineoplastic agents. The cytotoxic properties can be explained by the ability of quinones to generate active oxygen species by redox cycling, by addition to cellular nucleophiles, and by inhibition of DNA transcription. LÄS MER

  5. 4. Lysosomal Membrane Stability and Cathepsins in Cell Death

    Författare :Hanna Appelqvist; Karin Öllinger; Katarina Kågedal; Petra Wäster; Maria Shoshan; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. LÄS MER

  7. 5. Regulation of UV induced apoptosis in human melanocytes

    Författare :Cecilia Bivik; Inger Rosdahl; Karin Öllinger; Maria Shoshan; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; UV; melanocyte; lysosome; cathepsin; Bcl-2; Bax; Hsp70; JNK; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. LÄS MER