Sökning: "cytochrome P-450"

Visar resultat 11 - 15 av 25 avhandlingar innehållade orden cytochrome P-450.

  1. 11. Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis

    Författare :Doaa Elsherbiny; Ulrika Simonsson; Mats Karlsson; Lars Ståhle; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Drug-drug interactions; Cytochrome P-450; Artemisinin antimalarials; Nevirapine; Lopinavir; Rifampicin; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Malaria, Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are global health problems having their worst situation in sub-Saharan Africa. Consequently, concomitant use of antimalarial, antiretroviral and antitubercular drugs may be needed, resulting in a potential risk of drug-drug interactions. LÄS MER

  3. 12. Properties and hormonal regulation of polycyclic aromatic hydrocarbon metabolism by the cytochrome P-450 system in the mammalian ovary

    Författare :Margot Bengtsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 13. Studies on oxysterols : origins, properties and roles

    Författare :Steve Meaney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytochrome P-450; oxysterols; cholesterol homeostasis;

    Sammanfattning : Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished by their miscibility with plasma cholesterol. LÄS MER

  5. 14. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282

    Författare :Vladimir Sharoyko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin secretion; pancreatic islets; imidazolines; BL11282; arachidonic acid; phospholipase; cytochrome P-450; GLP-1; desensitization; Rhes;

    Sammanfattning : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. LÄS MER

  7. 15. 2-acetylaminofluorene : metabolism and effects on drug-metabolizing enzymes

    Författare :Anders Åström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : 2-Acetylaminofluorene has been found to have two different kinds of effects on drug-metabolizing enzymes in rat liver :1. Short-term treatment with this compound induces the level of microsomal epoxide hydrolase and cytochromes P-450b+e, c, d and PB/PCN-E, with a concominant increase in the metabolism of 2-acetylaminoflurene itself. LÄS MER