Sökning: "TLE"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet TLE.

1. 1. Advanced clinical MRI for better outcome in epilepsy surgery. Focusing on fMRI and prediction of verbal memory decline

   Författare :Maria Strandberg; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T MRI; surface coils; epilepsy surgery; fMRI; TLE; lateralization index; MTL; verbal encoding;

   Sammanfattning : Abstract Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface coils. LÄS MER

3. 2. Enhancing neuronal inhibition by cell and gene therapy as a novel treatment for Epilepsy

   Författare :Ana Gonzalez Ramos; Epilepsicentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Interneurons; GABA; Human pluripotent stem cells; Cell therapy; Gene therapy; Chemogenetics; Hippocampus; TLE; Cntnap2;

   Sammanfattning : Epilepsy is a family of heterogeneous and multifactorial neurological disorders, unified by the occurrence of spontaneous recurrent seizures. Overall, it affects 50 million people worldwide of all ages and genders. LÄS MER

4. 3. Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation

   Författare :Jenny Almqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :EBV; Oct-1; Oct-2; Groucho; TLE; transcription; repression; latency;

   Sammanfattning : The human herpes virus Epstein-Barr virus (EBV) is carried by approximately 95% of the adult population. It can form a lifelong latent infection in the B-cells by avoiding our immune system. A latent EBV infection is usually asymptomatic but a few EBV associated cancer forms has been described (e.g. LÄS MER

5. 4. Predictors of Verbal Memory Deficits from Temporal Lobe Surgery in Epilepsy. : Improving patient selection by investigation of methods used for predicting verbal memory following surgery

   Författare :Hanna Ljung; Helsingborg Kliniska Vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Verbal memory; TLE; TLR; verbal memory tests; depth electrodes; 7 Tesla MRI; fMRI;

   Sammanfattning : .... LÄS MER

7. 5. Gene therapy in epilepsy: neuropeptides and neurotrophic factors

   Författare :Irene Kanter Schlifke; Lund Wallenberg Neurocentrum; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; neuropsychology; Neurology; piriform cortex; hippocampus; neuropsykologi; encapsulated cells; viral vectors; GDNF; galanin; epilepsy; gene therapy; neurofysiologi;

   Sammanfattning : Temporal lobe epilepsy (TLE) is the most common form of epilepsy among adult patients, and the most problematic one as seizures cannot be controlled by currently available drugs in 30 % of patients. Gene therapy based on overexpression of endogenous anti-epileptic agents such as the neuropeptide galanin and the glial cell line-derived neurotrophic factor (GDNF) represents a promising new approach for treatment of TLE. LÄS MER