Sökning: "Seija Grénman"
Hittade 4 avhandlingar innehållade orden Seija Grénman.
1. Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma
Sammanfattning : This thesis focuses on the involvement of apoptosis and proliferation in the mechanisms of menstruation and hormonal replacement therapy, HRT, as well as in the mechanisms of progesterone therapy in endometrial carcinoma. The aim of the first study was to investigate endometrium for 4 days before and for 2 days during menstruation. LÄS MER
2. Prognostic Factors in Early Stages (FIGO I-II) of Epithelial Ovarian Carcinoma
Sammanfattning : From January, 1988, to December, 1993, 113 patients with FIGO stage IA-IIC epithelial ovarian carcinoma were treated with postoperative radiotherapy. The median follow-up period was 74 months. Tumor recurrences were recorded in 33 cases (30%). The cancer-specific survival rate was 72%. LÄS MER
3. Ovarian tumours, cell isolation, cell survival and sex steroids
Sammanfattning : Background: Ovarian cancer is the most deadly malignancy of the female reproductive tract. Ovarian epithelial tumours are considered to be endocrine related, but the factors that govern their genesis and progression remain unclear. Radical surgery and recent advances in chemotherapy have only moderately improved survival rates. LÄS MER
4. Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development
Sammanfattning : The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were analysed with the short-term Fluorometric Microculture Cytotoxicity Assay (FMCA). LÄS MER