Sökning: "Proteinfosforylering"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Proteinfosforylering.

  1. 1. Salt-inducible kinases in adipose tissue

    Författare :Johanna Sernevi Säll; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; salt-inducible kinase; SIK; SIK2; fettväv; fettceller; insulinsignalering; glukosupptag; fetma; insulinresistens; salt-inducible kinase; SIK; SIK2; adipose tissue; adipocytes; insulin signalling; glucose uptake; obesity; insulin resistance;

    Sammanfattning : Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. LÄS MER

  3. 2. Protein kinases in hormonal regulation of adipocyte metabolism

    Författare :Christine Berggreen; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Sammanfattning : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. LÄS MER

  4. 3. Insulin Signalling and Regulation of Protein Kinase B in Adipocytes

    Författare :Olga Göransson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; PDK1; PKB; diabetes; insulin; adipocyte;

    Sammanfattning : Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. LÄS MER

  5. 4. LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2

    Författare :Emma Henriksson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; signal transduction; protein phosphorylation; LKB1; SIK2; SIK3; cAMP;

    Sammanfattning : Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. LÄS MER

  7. 5. Signalling in plant mitochondria. Redox regulation of gene expression & characterisation of a pea nucleoside diphosphate kinase

    Författare :Martha L Escobar Galvis; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondrial gene expression; redox; respiratory complex II; NDPK; protein interactions; heat-stress; Växtbiokemi; Plant biochemistry;

    Sammanfattning : This work contributes to our understanding of mitochondrial responses to changing environmental conditions in plants. The first part of this thesis is focused in the study of redox regulation of mitochondrial gene expression. By using inhibitors, the redox state of the components of the mitochondrial respiratory chain was selectively affected. LÄS MER