Sökning: "Mevalonate pathway"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Mevalonate pathway.

  1. 1. Mevalonate pathway end-products : metabolism, utilization and regulation

    Författare :Anders Thelin; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  3. 2. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications

    Författare :Parmida Ranji; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mevalonate pathway; C. elegans; atfs-1; mitochondrial unfolded response UPR ;

    Sammanfattning : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. LÄS MER

  4. 3. Following the mevalonate pathway to bone heal alley

    Författare :Björn Skoglund; Lars Nordsletten; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; Pharmaceutical chemistry; Farmaceutisk kemi; Other veterinary medicine; Övrig veterinärmedicin;

    Sammanfattning : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. LÄS MER

  5. 4. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Författare :Siavash Partow; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Sammanfattning : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. LÄS MER

  7. 5. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis

    Författare :Lena M Henriksson; Torsten Unge; Sherry L. Mowbray; Barbara Seaton; Uppsala universitet; []
    Nyckelord :Molecular biology; Mycobacterium tuberculosis; Rv0009; peptidyl-prolyl cis-trans isomerase; Rv2870c; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; non-mevalonate pathway; DOXP MEP pathway; X-ray crystallography; Molekylärbiologi;

    Sammanfattning : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. LÄS MER