Sökning: "Lars Nordsletten"

Hittade 4 avhandlingar innehållade orden Lars Nordsletten.

  1. 1. Wnt signaling and metaphyseal bone healing

    Författare :Fredrik Agholme; Per Aspenberg; Lars Nordsletten; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : This thesis relates to some new aspects on the regulation of bone healing. In the last few years, Wnt-signaling has been shown to play a central role in bone biology. As well as being involved in bone maintenance and repair, Wnt-signaling has been presented as one of the key pathways through which bone responds to mechanical load. LÄS MER

  3. 2. Wear and Fixation of the acetabular component : in vivo evaluation of different polyethylenes and modes of fixation in total hip arthroplasty

    Författare :Stephan Maximilian Röhrl; Kjell Gunnar Nilsson; Bo Nivbrant; Lars Nordsletten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; total hip arthroplasty; acetabular component; wear; fixation; osteolysis; Radiostereometry; RSA; Kirurgi; Surgery; Kirurgi; ortopedi; Orthopaedics;

    Sammanfattning : Polyethylene wear and micromotion of the implant play an important role in multifactorial etiology of osteolysis leading to aseptic loosening of the acetabular components. Despite excellent results in primary total hip arthoplasty in a 10-15 year perspective there are still unsolved problems. LÄS MER

  4. 3. Following the mevalonate pathway to bone heal alley

    Författare :Björn Skoglund; Lars Nordsletten; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; Pharmaceutical chemistry; Farmaceutisk kemi; Other veterinary medicine; Övrig veterinärmedicin;

    Sammanfattning : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. LÄS MER

  5. 4. Influence of Oxidative Stress on Muscle and Bone

    Författare :Bengt Östman; Karl Michaëlsson; Lars Nordsletten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mineral density; coenzyme Q10; exercise; ischaemia; isprostanes; muscle; oxidative stress; oxygen radicals; reperfusion; tocopherol; Orthopaedics; Ortopedi; ortopedi; Orthopaedics;

    Sammanfattning : Reactive oxygen species (ROS) induce oxidative stress and although are primarily recognized for playing a deleterious biological role, they can be beneficial to cell systems. ROS are extremely short-lived and normally tightly regulated by antioxidant defence systems. LÄS MER