Sökning: "GRN"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet GRN.

  1. 1. Towards Reliable Gene Regulatory Network Inference

    Författare :Daniel Morgan; Erik Sonnhammer; John Quackenbush; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GRN; network inference; biological systems; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : Phenotypic traits are now known to stem from the interplay between genetic variables across many if not every level of biology. The field of gene regulatory network (GRN) inference is concerned with understanding the regulatory interactions between genes in a cell, in order to build a model that captures the behaviour of the system. LÄS MER

  3. 2. The role of leptin in zebrafish (Danio rerio) : Novel insights into appetite regulation and reproduction

    Författare :Emmanouil Tsakoumis; Monika Schmitz; Tatjana Haitina; Åsa Wallén-Mackenzie; Ana Gómez Peris; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; zebrafish; leptin; appetite; GRN; brain; reproduction; oocyte maturation; ovulation; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Sammanfattning : The hormone leptin is a peripheral metabolic signal and an important regulator of energy balance. In mammals, leptin acts on the appetite centers in the hypothalamus, causing anorexigenic functions by inhibiting food intake. It is also considered as a link between the nutritional status and the endocrine reproductive axis. LÄS MER

  4. 3. Exploring the Boundaries of Gene Regulatory Network Inference

    Författare :Andreas Tjärnberg; Erik Sonnhammer; Richard Bonneau; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GRN; gene regulatory network; network inference; signal to noise ratio; model selection; variable selection; data properties; reverse engineering; ordinary differential equations; gene networks; linear regression; lasso; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : To understand how the components of a complex system like the biological cell interact and regulate each other, we need to collect data for how the components respond to system perturbations. Such data can then be used to solve the inverse problem of inferring a network that describes how the pieces influence each other. LÄS MER

  5. 4. Genetic characterization of patients with frontotemporal dementia and amyotrophic lateral sclerosis in the Nordic countries

    Författare :Huei-Hsin Chiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Frontotemporal dementia (FTD) is the second most common form of neurodegenerative disease affecting people under the age of 65 years. The general symptoms are dysfunctions in behavior and/or language. LÄS MER

  7. 5. In silico modelling for refining gene regulatory network inference

    Författare :Thomas Hillerton; Erik L. L. Sonnhammer; Richard Bonneau; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Gene regulatory networks; simulation; benchmarking; method development; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Sammanfattning : Gene regulation is at the centre of all cellular functions, regulating the cell's healthy and pathological responses. The interconnected system of regulatory interactions is known as the gene regulatory network (GRN), where genes influence each other to maintain strict and robust control. LÄS MER