Sökning: "toxikologi mikrobiologi"

Visar resultat 11 - 15 av 88 avhandlingar innehållade orden toxikologi mikrobiologi.

1. 11. Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity

   Författare :Siamak Haghdoost; Mats Harms-Ringdahl; Steffen Loft; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidative stress; 8-oxo-dG; 8-oh-dG; Radiosensitivity; Toxicology; Toxikologi;

   Sammanfattning : Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. LÄS MER

3. 12. Interplay between DNA repair pathways at replication forks in mammalian cells

   Författare :Fredrik Johansson; Dag Jenssen; Klaus Erixon; Harry Vrieling; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

   Sammanfattning : Cellular DNA is continuously being damaged by various agents of both endogenous and exogenous origin including a wide range of chemical compounds, UV-light and ionizing radiation. In order to remove lesions from the DNA and maintain genomic stability, different repair processes have evolved. LÄS MER

4. 13. Factors Influencing the Yield of Mutations Induced by Polycyclic Aromatic Hydrocarbons in Mammalian Cells

   Författare :Anne Lagerqvist; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Hanspeter Naegeli; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Toxicological Genetics;

   Sammanfattning : Environmental contaminants are ubiquitously present in the urban environment, this has the implication that humans are exposed to toxic and carcinogenic chemicals. Polycyclic aromatic hydrocarbons (PAH) are one type of environmental contaminants, which are produced by combustion of organic compounds. LÄS MER

5. 14. Involvement of Homologous Recombination in Response to Different Qualities of DNA Damage

   Författare :Gunilla Olsson; Mats Harms-Ringdahl; John Thacker; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

   Sammanfattning : The present studies aimed at elucidate the role of homologous recombination (HR) for the repair of different qualities of DNA damages and/or changes in chromatin structure induced by a variety of radiation qualities.Radiation qualities used to expose cells in culture ranged from non-ionizing radiation with extremely low frequency (ELF), of energies too low to disrupt chemical or molecular bonds, to radiation qualities with energies able to induce ionizations and break chemical bonds. LÄS MER

7. 15. Induction of apoptosis in relation to chromatin structure and inhibition of replication by DNA damage from ionizing radiation

   Författare :Jesper Torudd; Mats Harms-Ringdahl; Mats Ljungman; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; DNA-loop; replication fork; Toxicology; Toxikologi;

   Sammanfattning : The theme of this thesis has been chromatin organization ranging from methodological studies to involvement in apoptotic response. The aims have been: (i) to compare the information obtained by the AVTD method and comet assay concerning DNA-loop organization, (ii) to test the hypothesis that DNA-loop relaxation could be the triggering signal for induction of apoptosis in G0-lymphocytes, and (iii) to study the dose response for inhibition of the replication fork movement and pathways for the DNA repair process at the replication fork. LÄS MER