Sökning: "retinoid X receptor"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden retinoid X receptor.

  1. 1. Finding the ligand : retinoid receptor activation in the CNS

    Författare :Alexander Mata de Urquiza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear hormone receptors (NRs) comprise a large family of ligand activated transcription factors, found in vertebrates, arthropods and nematodes. Among the members of the NR family are the receptors for small, lipophilic ligands such as the steroid hormones, vitamins A and D, thyroid hormone oxysterols and bile acids. LÄS MER

  3. 2. Studies on Vitamin A Signaling in Psoriasis : A Comparison Between Normal and Lesional Keratinocytes

    Författare :Teresa Karlsson; Jan Öivind Moskaug; Uppsala universitet; []
    Nyckelord :Medical sciences; Psoriasis; vitamin A; retinoids; retinoid receptor; differentiation; keratinocyte; skin; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

    Sammanfattning : Vitamin A and metabolites (retinoids) are crucial for normal epidermal maturation. Physiological effects are mediated by retinoic acid (RA) that activates nuclear retinoic acid receptors (RARs) in complexes with retinoid X receptors (RXRs), resulting in altered gene transcription.Psoriasis is a common disease with unknown etiology. LÄS MER

  4. 3. Functional studies on the orphan receptor Nurr1 and related retinoid receptors

    Författare :Diogo Sampaio e Castro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors (NRs) constitute a large family of ligand-inducible transcription factors which includes receptors for steroid hormones, retinoids (vitamin A derivatives), vitamin D an d thyroid hormone. The family also includes a large number of structurally related proteins that lack identified ligands and are therefore refered to as orphan receptors. LÄS MER

  5. 4. Determinants of ligand-induced nuclear receptor activation

    Författare :Tove Östberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid hormones and retinoids and play an important role in cellular regulation. LÄS MER

  7. 5. Native protein mass spectrometry of nuclear receptor-ligand and enzyme-substrate complexes

    Författare :Johan Lengqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mass spectrometry; electrospray; nuclear receptor; retinoid X receptor; fatty acid; membrane protein; glutathione transferase; glutathione;

    Sammanfattning : Nuclear receptors (NRs) are transcription factors that are activated by the binding of low molecular weight ligands. The NR superfamily includes receptors for steroid hormones, anti-inflammatory and lipid-lowering drugs as well as endogenous compounds such as bile acids and fatty acids. LÄS MER