Sökning: "purinergic signaling"
Visar resultat 16 - 20 av 20 avhandlingar innehållade orden purinergic signaling.
16. Membrane lipids and their transfer proteins in β-cells
Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER
17. On neuroinflammation in psychotic disorders
Sammanfattning : Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms and impaired executive functioning. LÄS MER
18. Experimental inhibition of proliferative retinopathy
Sammanfattning : Retinal ischemic diseases like retinopathy of prematurity (ROP), diabetic retinopathy (DRP) and retinal vein occlusion, with preretinal neovascularization (angiogenesis) that may lead to vitreous hemorrhages and retinal detachment with subsequent vision loss and blindness is a global health problem. By analyzing the potential role of molecules acting at different levels of the angiogenic cascade the presented studies aimed to widen our understanding of retinal ischemic diseases on a molecular, cellular and morphologic level. LÄS MER
19. The role of red blood cells in cardiac and endothelial dysfunction in cardiometabolic disease
Sammanfattning : Background: Cardiometabolic disease, which includes the combination of cardiovascular disease, especially coronary artery disease and type 2 diabetes (T2D), is a major health problem and cause of mortality worldwide. ST-elevation myocardial infarction (STEMI) occurs when coronary arteries are occluded and is regarded as a life-threatening disorder. LÄS MER
20. Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
Sammanfattning : Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets in patients who suffer from the long term side effects of diabetes and insulin therapy. LÄS MER