Sökning: "purinergic signaling"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden purinergic signaling.

1. 11. Novel Agonists and Antagonists of Platelet Receptors

   Författare :Carl Högberg; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Platelets; P2Y12; SUCNR1; FPP; hypothermia;

   Sammanfattning : Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. LÄS MER

3. 12. Regulatory Functions of the Juxtaglomerular Apparatus

   Författare :Ruisheng Liu; Ole Skott; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; mesangial; desensitization; nitric oxide; calcium; P2Y receptor; macula densa; NaCl; luminal. microperfusion; angiotensin; Cellbiologi; Cell biology; Cellbiologi; Medicine; medicin;

   Sammanfattning : The tubuloglomerular feedback mechanism is an important regulator in the juxtaglomerular apparatus and it detects flow dependent alterations in luminal NaCl concentration ([NaCl]) at the macula densa (MD) cell site via a Na+-K+-2Cl cotransporter. Signals are sent by the MD to adjust the afferent arteriole tone and altering release of renin. LÄS MER

4. 13. A MATTER OF NUTRIENT EXCESS AND SHEAR STRESS

   Författare :Ramasri Sathanoori; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. LÄS MER

5. 14. Statin-induced cellular effects mediated by the P2X7 receptor

   Författare :Oras Mistafa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER

7. 15. The thrombin receptors PAR1 and PAR4 and their relative role in platelet activation

   Författare :Martina Nylander; Tomas Lindahl; Magnus Grenegård; Rolf Andersson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi;

   Sammanfattning : Many blood cell mechanisms in the human body are working all the time to maintain haemostasis in the blood vessels. Once a wound arises platelets are alerted via different substances to cover the wound and prevent loss of blood. Most of the times these mechanisms do stop the blood, and further heal the wound. LÄS MER