Sökning: "perinatal inflammation"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden perinatal inflammation.

  1. 1. Inflammation and Cell Profileration Following Perinatal Brain Injury

    Författare :Katarina Järlestedt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia; immature brain; reactive gliosis; complement system; C3a; fear conditioning; lipopolysaccharide; inflammation;

    Sammanfattning : Inflammation plays an important role in cerebral ischemic injury in the immature brain. The aim of the thesis was to investigate (1) the role of astrocyte activation and reactive gliosis in neonatal hypoxic-ischemic (HI) brain injury, (2) the role of complement derived peptide C3a in neonatal HI brain injury, (3) the effect of neonatal HI brain injury on fear learning and behaviour, (4) the effects of lipopolysaccharide (LPS) induced systemic inflammation on cell proliferation in the developing brain. LÄS MER

  3. 2. Very preterm infants and later lung function - impact of perinatal inflammation, club cell secretory protein and bronchopulmonary dysplasia

    Författare :Cecilia Hagman; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Preterm children; perinatal inflammation; club cell protein CC16 ; bronchopulmonary dysplasia; lung function; Respiratory health; immature;

    Sammanfattning : .... LÄS MER

  4. 3. Developing brain and systemic inflammation: a "Toll-like" link with consequences

    Författare :Amin Mottahedin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; developing brain; neonatal brain injury; hypoxia-ischemia; inflammation; infection; Toll-like receptor; choroid plexus; neuroimmunology; Mitochondria;

    Sammanfattning : The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. LÄS MER

  5. 4. Inflammation in the immature brain: The role of Toll like receptors

    Författare :Linnea Stridh; Göteborgs universitet; []
    Nyckelord :hypoxia-ischemia; immature brain; inflammation; innate immunity; Toll-like receptors;

    Sammanfattning : Infection/inflammation and/or hypoxia-ischemia (HI) are major causes of perinatal brain injury. Toll-like receptors (TLRs), important components of innate immunity, have been shown to be involved in brain injury, both after infectious and endogenous, non-infectious, stimuli. LÄS MER

  7. 5. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

    Författare :Pernilla Svedin; Göteborgs universitet; []
    Nyckelord :hypoxia-ischemia; LPS; immature; brain; inflammation; NAC; melatonin; G-2mPE; MMP-9; MMP-12;

    Sammanfattning : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. LÄS MER