Sökning: "neural specification"

Visar resultat 41 - 45 av 50 avhandlingar innehållade orden neural specification.

  1. 41. Molecular regulation of somatosensory neuron development

    Författare :Yiqiao Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The somatosensory system of vertebrates perceives and transmits a variety of information from both external and internal environments to the central nervous system where an integrated response is established leading to adaptive outcome. Specific classes of sensory neurons convey the information consisting of touch, muscle stretch, temperature, itch, and pain. LÄS MER

  3. 42. The Role of the SHB Adapter Protein in Cell Differentiation and Development

    Författare :Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
    Nyckelord :Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

    Sammanfattning : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. LÄS MER

  4. 43. Generation of cell diversity in the developing brainstem and its modeling in vitro

    Författare :Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. LÄS MER

  5. 44. Ionic modulators of stem cell state

    Författare :Anna Omelyanenko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tissue generation during development and maintenance throughout life relies on the proliferation and sequential specification of a group of cells. Stem cells are defined by the properties of self-renewal (division to produce daughter cells equipotent to the mother) and differentiation (division where at least one daughter is of a more restricted potential). LÄS MER

  7. 45. Single-cell analysis of mammalian cardiogenesis elucidating an essential role of outflow tract progenitors

    Författare :Chikai Zhou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The heart is the first organ to form and start to function during mammalian embryogenesis. This complex organ system is constructed by a diverse set of cell types, involving mesodermal precursors and heart progenitors, at the earliest embryonic stages. LÄS MER