Sökning: "membrane microdomains"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden membrane microdomains.

  1. 11. Studies of cell signalling using bacterial toxins and organic electronic devices

    Författare :Peter Kjäll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One of the most versatile biological signalling entities is the calcium ion, Ca2+. With a characteristic spatial and temporal signalling pattern, this universal second-messenger directs diverse cellular functions, e.g. secretion of neurotransmitters at the synaptic cleft to regulation of transcription and fertilization. LÄS MER

  3. 12. Regulation of docking and priming in pancreatic α- and β-cells

    Författare :Muhmmad Omar-Hmeadi; Sebastian Barg; Patrick MacDonald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type-2 diabetes; glucagon; insulin; somatostatin; exocytosis;

    Sammanfattning : The secretion of islet hormones from endocrine cells of the pancreas plays vital roles in maintaining glucose homeostasis. Dysfunction of these cells leads to diabetes, a devastating metabolic disorder affecting millions worldwide, but underlying mechanisms remain poorly understood. LÄS MER

  4. 13. Intricate aspects of the thioredoxin system in redox signaling

    Författare :Marcus Cebula; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all downstream events. These modifications can be reversed by redox catalysts of which the thioredoxin system forms one of the most prominent. LÄS MER

  5. 14. Involvement of lipid rafts in G protein-coupled monoamine receptor trafficking and signaling : a pharmacological approach

    Författare :Benita Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The present work focused on lipid raft-mediated modulation of signaling and trafficking of serotonin (5-HT) and dopamine receptors. The 5-HT system is one of the most complex neurotransmitter systems, with a wide distribution both in the CNS and in the periphery. LÄS MER

  7. 15. Receptor localization and dynamics of murine natural killer cells at single cell level : using advanced fluorescence microscopy

    Författare :Sunitha Bagawath Singh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural Killer (NK) cells are immune cells and important for the defense against virally infected and malignant cells. NK cells are regulated by germline encoded activating and inhibitory receptors. Activating receptors specifically recognize ligands which are either encoded by infectious agents, or induced upon infection or cellular stress. LÄS MER