Sökning: "manipulation therapy"

Visar resultat 16 - 20 av 36 avhandlingar innehållade orden manipulation therapy.

  1. 16. Cardiomyocyte Cell Cycle, Renewal and Isolation

    Författare :Stuart Walsh; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; binucleation; Cardiomyocytes; surface marker; troponin-T; mitosis; microarray; cell cycle; FACS;

    Sammanfattning : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. LÄS MER

  3. 17. Somatostatin effects on the proteome of human prostate cancer cells

    Författare :Zhaoxu Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transition of prostate cancer from androgen dependent to the therapy resistant androgen independent state, is a large and persistent problem in the clinical management of prostate cancer. The aim of this thesis was to study somatostatin effects on the proteome of prostate cancer cells, to identify differences in protein expression in androgen dependent and androgen independent prostate cancer cells, and to explore possibilities to enhance the somatostatin receptor expression through pre-treatment with sms, 5-aza and TSA (DNA methylation/HDAC inhibitors). LÄS MER

  4. 18. Geopolymer-based drug formulations for oral delivery of opioids

    Författare :Bing Cai; Susanne Bredenberg; Håkan Engqvist; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Opioid therapy for chronic pain generally use controlled release formulations to deliver analgesic drugs around-the-clock. Controlled release dosage forms can enlarge the therapeutic effect by controlling the rate and site of release. However, with high drug content, opioid formulations are easily targeted for non-medical use. LÄS MER

  5. 19. Investigating novel mechanisms for transcriptional memory using genetic engineering

    Författare :Yerma Pareja Sanchez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transcriptional memory is phenomenon that has gained interest due to its potential impact on human health. With our work, we wanted to contribute to the understanding of its regulation. To do so, we performed genome-wide knockout screens in both budding yeast and human cells. LÄS MER

  7. 20. Nucleic acid delivery : reports from the search of the magic bullet

    Författare :Joana Viola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene therapy is regarded as one of the most promising therapeutic approaches, since it has the potential to treat disorders by correcting malformations at the nucleic acids level rather than proteins, as opposed to conventional medicine. However, for non-viral gene therapy to successfully fulfill the requirements associated to the “magic bullet” has proven difficult. LÄS MER