Sökning: "hepatic steatosis"

Visar resultat 26 - 30 av 31 avhandlingar innehållade orden hepatic steatosis.

  1. 26. Dietary nitrate and the microbiota : modulators of metabolic function

    Författare :Chiara Moretti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nitric oxide (NO) deficiency represents a known feature of cardiovascular and metabolic diseases as well as natural aging. The NO metabolites nitrate and nitrite have long been considered as health-threatening food components with potential carcinogenic effects. LÄS MER

  3. 27. Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

    Författare :Angela Molinaro; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin signaling; PI3Ks; PI3K isoform-selective inhibitors;

    Sammanfattning : Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity to these diseases remains largely unresolved. LÄS MER

  4. 28. Studies on the mechanisms of action and physiological relevance of SOCS proteins

    Författare :Fahad Al-Zadjali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Understanding systemic biological pathways and the key cellular mechanisms that dictate disease states, drug response, and altered cellular function in metabolic disorders is a significant challenge. Research in the last 20 years have made it clear that tissue communication, through the actions of endocrine, paracrine or autocrine factors play a significant role in pathogenesis of complex multiorgan diseases such as the metabolic syndrome. LÄS MER

  5. 29. Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism

    Författare :Mikael Bjursell; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Energy homeostasis ? the balance of energy intake, expenditure, and storage ? is controlled by autonomic regulation originating in the hypothalamus and the brain stem, which receive input from the periphery. Upon receiving signals from the periphery, centres in the central nervous system (CNS) react through endocrine or neuronal responses to maintain a steady balance. LÄS MER

  7. 30. Cytokines, alcohol metabolizing enzymes and stress-inducible ER proteins in alcoholic liver disease

    Författare :Che Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The release of inflammatory cytokines by Kupffer cells is believed to be a key step in the pathogenesis of alcoholic liver disease (ALD). Kupffer cells are activated not only by endotoxins [lipopolysaccharides (LPS)] but also by the lipid peroxidation products generated mainly via ethanol-inducible cytochrome P450 2E1 (CYP2E1) redox cycling. LÄS MER