Sökning: "elisabet Åkesson"

Hittade 3 avhandlingar innehållade orden elisabet Åkesson.

  1. 1. Human spinal cord transplantation : experimental and clinical application

    Författare :Elisabet Åkesson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objectives of this Thesis was to further characterize the in situ human first trimester spinal cord tissue and to evaluate the survival, integration and possible neurological effects of solid human embryonic spinal cord grafts transplanted to cavities in the spinal cord of rat and man. Human-specific neurofilament and Thy-1 positive fibers were observed already at 5 weeks of gestation in the in situ human spinal cord, the earliest stage at which donor tissue was used for intraspinal transplantation. LÄS MER

  3. 2. Interaction between nerve fiber formation and astrocytes

    Författare :Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

    Sammanfattning : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. LÄS MER

  4. 3. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER