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1. 1. Hypoxic pulmonary vasoconstriction and nitric oxide

   Författare :Kristina Hambraeus Jonzon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :hypoxia; pulmonary vasoconstriction; regional pulmonary bloodflow; stimulus-response; nitric oxide; blood-borne distant effects; nitric oxide synthase activity; inhaled; exhaled; non-enzymatic;

   Sammanfattning : Hypoxia causes pulmonary vasoconstriction (HPV), improving oxygenation by redistribution of the pulmonary blood flow to better oxygenated lung regions. HPV is intrinsic to the pulmonary vascular smooth muscle cell, but can be modulated by several vasoactive substances, as for example endothelium derived nitric oxide (NO) and endothelin-1 (ET-1). LÄS MER